• Report Number: 1885201

Reports Overview

The global CAR-T cell therapy market was valued at US$ 72.0 Mn in 2017 expanding at a CAGR of 51.1% from 2018 to 2026. report highlights the ongoing clinical and non-clinical advancement in the field of Car T Cell Therapy. As per report findings, the promise of CAR modified T cell therapy derives from its combined immunologic benefits and include the specificity of a targeted antibody, the ability to expand the T cell population and the potential for long term persistence to facilitate the ongoing tumor surveillance. The success in early phase trials, assess the feasibility of evaluating the treatment modality across the multiple centers and in larger patients. Currently, there are 99 CAR T Cell based therapies in clinical pipeline and most of them belong to Phase-I and Phase-I/II clinical trials. 

In recent years, researchers have identified the chimeric antigen receptor as a potential target for molecular genetics to insert a new epitopes on the receptor region which allows a degree of control of the immune system. CAR T cell therapy satisfy the need to explore new and efficacious adoptive T cell therapy. The gene transfer technology could efficiently introduce the genes encoding CARs into the immune effector cells. The transferring of engineered T cells provides the specific antigen binding in a non-major histocompatibility complex. 

The promise of CAR modified T cell therapy derives from its combined immunologic benefits and include the specificity of a targeted antibody, the ability to expand the T cell population and the potential for long term persistence to facilitate the ongoing tumor surveillance. The success in early phase trials, assess the feasibility of evaluating the treatment modality across the multiple centers and in larger patients. 

The first commercial application of CAR T Cell based therapy for the treatment of Mantle- Non-Hodgkin’s lymphoma is expected to be available from 2020. The anti-CD19 CAR T cell therapy axicabtagene ciloleucel (KTE-C19) is developed by KITE Pharma in collaboration with National Cancer Institute. Currently this therapy is in preregistration phase. 

In future, the advancement of CAR T Cell therapy will be largely driven by academia and will require the support for the expensive early phase clinical trials which promise to cover the way for a new form of targeted, exportable immunotherapy for cancer patient. The manufacturing of CD19 CAR T cell therapy CTL019 is in a way which will modernize the process of using the therapy globally. The anticipation of regulatory and manufacturing issues before they arise and proactively addressing the concerns helps to accelerate the process of bringing this promising therapeutic approach to more patients in future.

Rising Prevalence of Blood Cancers to Augment the Growth of CAR-T Cell Therapy Market

The non-Hodgkin’s lymphoma segment dominated the market in 2017 owing to a surge in the number of NHL cases coupled with the higher adoption of YESCARTA (axicabtagene ciloleucel) and Kymriah (tisagenlecleucel, formerly CTL019) around the world. CAR T cell therapy products are currently indicated in non-Hodgkin’s lymphoma, acute lymphocytic leukemia, and chronic lymphocytic leukemia only. However, clinical trials of some CAR T cell therapy drugs being studied (under study) for the treatment of multiple myeloma, acute myeloid leukemia, melanoma, glioblastomas, myelodysplastic syndromes (MDS), and cancer of pancreatitis, prostate, bladder, esophagus, stomach, liver, lung, kidney, & cervix. Thus, proliferating application of CAR-T in various indication would further boost the market during the forecast period.

Increasing Adoption of CAR-T Cell Therapy in North America will Drive Swift Growth during the Forecast Period

In 2017, North America demonstrates supremacy in the global CAR-T cell therapy market owing to the exclusive availability of the two approved products Kymriah (Novartis AG) and Yescarta (Gilead Sciences, Inc.). Developed healthcare infrastructure, high accessibility to advanced therapies, rise in healthcare expenditure, incessant investment in R&D activities, and presence of established market leaders further catalyzes the overall market growth in this region. With Medicare constantly working on structuring suitable reimbursement policies for dynamically priced CAR-T cell therapies, the demand for it is projected to increase during the forecast period. In Asia Pacific, the market entry of Kymriah expected by end of 2018 in Japan. The extensive pipeline portfolio for CAR-T cell therapy in China and the continuous growing cancer prevalence in Asia Pacific regions predominantly contribute to the maximum growth.

Key questions answered in this report

How the global CAR-T cell therapy market will perform during the forecast period from 2018 to 2026?
What are the latest trends in the CAR-T cell therapy market and valuable opportunities for key players?
Who are the leading players in the global CAR-T cell therapy market?
Which is the leading/and fastest region in the global CAR-T cell therapy market?
Currently, what are the reimbursement scenario and regulatory structure for the CAR-T cell therapy?
What are drivers and restrains governing the global CAR-T cell therapy market?
What is the pipeline scenario of the global CAR-T cell therapy market?
Which indications are being targeted using CAR-T cell therapy?
What is the status of the clinical trials studied for various antigens?

Table Of Content

Chapter 1 Preface
1.1 Report Description
1.1.1 Study Purpose
1.1.2 Target Audience
1.1.3 USP and Key Offerings
1.2 Research Scope
1.3 Research Methodology
1.3.1 Phase I – Secondary Research
1.3.2 Phase II – Primary Research
1.3.3 Phase III – Expert Panel Review
1.3.4 Assumptions

Chapter 2 Executive Summary
2.1 Global CAR-T Cell Therapy Market Portraiture
2.2 Global CAR-T Cell Therapy Market, by Indication, 2017 vs 2026 (Value %)
2.3 Global CAR-T Cell Therapy Market, by Geography, 2017 vs 2026 (Value %)

Chapter 3 Global CAR-T Cell Therapy Market: Dynamics and Future Outlook
3.1 Overview
3.2 Market Drivers
3.2.1 Emerging Immuno-Oncology in Clinical Cancer Research
3.2.2 Rising Prevalence of Cancer
3.3 Challenges
3.3.1 High Cost of CAR-T Cell Therapy
3.4 Opportunities
3.4.1 Mergers and Acquisition in the CAR-T Cell Therapy Market
3.4.2 CAR-T Cell Therapy Beyond Cancer Treatment
3.5 Attractive Investment Proposition: Global CAR-T Cell Therapy Market, by Indication, 2018
3.6 Competitive Analysis: Global CAR-T Cell Therapy Market, 2017

Chapter 4 Global CAR T Cell Therapy Market, by Targeted Antigen, 2017-2026 (US$ Mn)
4.1 Overview
4.1.1 Global CAR T Cell Therapy Market, by Targeted Antigen, 2017 – 2026 (US$ Mn)
4.1.2 CD 19
4.2 Pipeline Therapy Analysis
4.2.1 CD 20
4.2.2 CD 22
4.2.3 CD 30
4.2.4 CD 33
4.2.5 GD 2
4.2.6 HER 2
4.2.7 MESO
4.2.8 EGFRvIII
4.2.9 Major Clinical-stage CAR-T projects with commercial licensees

Chapter 5 Global CAR T Cell Therapy Market, by Indication, 2017-2026 (US$ Mn)
5.1 Overview
5.2 Non-Hodgkin’s Lymphoma
5.3 Acute Lymphocytic Leukemia
5.4 Chronic Lymphocytic Leukemia

Chapter 6 Global CAR-T cell Therapy Market, by Geography, 2017 – 2026 (US$ Mn)
6.1 Overview
6.1.1 Global CAR-T cell Therapy Market, by Geography, 2017 – 2026 (US$ Mn)
6.2 North America
6.2.1 North America CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.2.2 North America CAR-T cell Therapy Market, by Country, 2017 – 2026 (US$ Mn)
6.2.2.1 U.S. CAR-T cell Therapy Market, 2017 – 2026 (US$ Mn)
6.2.2.2 Canada CAR-T cell Therapy Market
6.3 Europe
6.3.1 Europe CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.3.2 Europe CAR-T cell Therapy Market, by Country/Region, 2017 – 2026 (US$ Mn)
6.3.2.1 United Kingdom CAR-T cell Therapy Market
6.3.2.2 Germany CAR-T cell Therapy Market
6.3.2.3 Rest of Europe CAR-T cell Therapy Market
6.4 Asia Pacific
6.4.1 Asia Pacific CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.4.2 Asia Pacific CAR-T cell Therapy Market, by Country/Region, 2017 – 2026 (US$ Mn)
6.4.2.1 Japan CAR-T cell Therapy Market
6.4.2.2 China CAR-T cell Therapy Market
6.4.2.3 Rest of Asia Pacific CAR-T cell Therapy Market
6.5 Rest of World
6.5.1 Latin America
6.5.2 Latin America CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)
6.5.2.1 Mexico CAR-T cell Therapy Market
6.5.2.2 Brazil CAR-T cell Therapy Market
6.5.2.3 Rest of Latin America CAR-T cell Therapy Market
6.5.3 Middle East & Africa
6.5.4 Middle East & Africa CAR-T cell Therapy Market, by Indication, 2017 – 2026 (US$ Mn)

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